Efficacy and safety of non-vitamin K antagonist oral anticoagulants compared with warfarin in patients with atrial fibrillation.

Non-vitamin K antagonist oral anticoagulants reduce all-cause mortality, major bleeding and intracerebral hemorrhage but higher risk of gastro-intestinal bleeding according to a recent study including 18638 patients treated with DOACs versus 49418 on warfarin in Sweden.
Friberg L and Oldgren J. Open Heart 2017. https://www.ncbi.nlm.nih.gov/pubmed/29018536